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SELECTED PUBLICATIONS

Research: Project

2023

Ho et al Cell Reports.jpg
Model of alpha cell regulation by glucose and leucine for Knuth et al (2).png

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Ho T, Potapenko E, Davis DB, and Merrins MJ..

Cell Reports. 2023.​ 

Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMP

Knuth ER, Foster HR, Jin E, and Merrins MJ.

Biorxiv. 2023.​ 

2022

Figure 1 PK isoform paper - Figure Set_2022-07-29_Page_1_edited.jpg

Metabolic cycles and signals for insulin secretion

Merrins MJ, Corkey BE, Kibbey RG, Prentki M.

Cell Metabolism. 2022.​ 

β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel

Foster HR, Ho T, Potapenko E, Sdao SM, Huang SM, Lewandowski SL, VanDeusen HR, Davidson SM, Cardone RL, Prentki M, Kibbey RG, and Merrins MJ.

eLife. 2022.​ 

Cycling Review Figures v14_resubmission_2022-05-11_Page_1_edited.jpg

2021

CDK2 Sdao graphical abstract.PNG
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CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure

Sdao SM, Ho T, Poudel C, Foster HR, De Leon ER, Adams MT, Lee JH, Blum B, Rane SG, and Merrins MJ.

Cell Reports. 2021.​ 

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Corkey BE, Deeney JT, and Merrins MJ.

Diabetes. 2021.​ 

2020​

Lewandowski%20Graphical%20Abstract_edite
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2019​

Phasor plot.PNG

2018​

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2017​

PET imaging.PNG

2016​

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Pancreatic β-cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

Gregg T†, Poudel C†, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW*, Merrins MJ*.​

Diabetes. 2016.

Laboratory of Matthew J. Merrins, Ph.D.

University of Wisconsin-Madison

©2014-2019 Merrins Lab

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