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for the study of islet biology.
LABORATORY OF MATTHEW J. MERRINS, Ph.D.
University of Wisconsin-Madison
Research: Project
2023
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A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMP
2022
Metabolic cycles and signals for insulin secretion
β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel
eLife. 2022.
2021
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CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure
Sdao SM, Ho T, Poudel C, Foster HR, De Leon ER, Adams MT, Lee JH, Blum B, Rane SG, and Merrins MJ.
Cell Reports. 2021.
What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?
2020
2019
2018
2017
2016
Gregg T†, Poudel C†, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW*, Merrins MJ*.
Diabetes. 2016.
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